Generation of Cross-Protective Antibodies against Plasmodium falciparum Sequestration by Immunization with an Erythrocyte Membrane Protein 1–Duffy Binding-Like 1 Domain †
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چکیده
Generation of Cross-Protective Antibodies against Plasmodium falciparum Sequestration by Immunization with an Erythrocyte Membrane Protein 1–Duffy Binding-Like 1 Domain † Kirsten Moll, Fredrik Pettersson, Anna M. Vogt, Cathrine Jonsson, Niloofar Rasti, Sanjay Ahuja, Mats Spångberg, Odile Mercereau-Puijalon, David E. Arnot, Mats Wahlgren, and Qijun Chen* Microbiology and Tumorbiology Center, Karolinska Institutet, and Swedish Institute for Infectious Disease Control, 171 77 Stockholm, Sweden; Department of Nuclear Medicine, Karolinska University Hospital, Solna, Sweden; Parasite Molecular Immunology Unit, CNRS URA 2851, Pasteur Institute, Paris, France; and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
منابع مشابه
Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein 1-duffy binding-like 1 alpha domain.
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important virulence factor on the surface of infected erythrocytes. Naturally acquired antibodies to PfEMP1 expressed by parasites causing severe malaria are suggested to be protective and of major interest for the development of a vaccine against severe disease. In this study, the PfEMP1 expressed by a parasite clone displ...
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